But while many took those tweets as an indication that the President was feeling uneasy about the potential embarrassment of having a Democrat take the seat, Trump himself appeared to take credit for Ossoff's loss in a follow-up tweet Tuesday night.
In some ways, it worked. Democrats mostly consolidated support behind Ossoff, a 30-year-old filmmaker and former congressional aide.
Mmm, 48 percent is "narrowly"?
The Republican candidate received nearly 20 percent of the vote on Tuesday in a primary to fill the House seat vacated by Health and Human Services Secretary Tom Price.
"There is no doubt that this is already a victory for the ages", Ossoff told his ecstatic supporters Tuesday night. "It is deep! It is. foul".
That's partly because Ossoff's GOP opponent, Handel, comes with baggage. It drew 11 Republicans, five Democrats, and three independents.
Although Ossoff took the lead in the results, all of the Republicans in the race earned a combined 51 percent, indicating that Handel is still likely to do well in June. "Do they get behind her or do they not?" In 2010, she was defeated in a governor's race by Nathan Deal.
She opens the book by taking the reader back to a pivotal moment - an interview with the head of Komen, Nancy Brinker, by NBC's Andrea Mitchell, whom Handel bitterly derides on Page 1 as "an ardent liberal and breast cancer survivor" who was "enraged" at Komen's decision to cut off funding.
But with Handel's political experience comes baggage. The race was a contentious one as Deal attacked her for being a part of the Log Cabin Republicans, the LGBT group within the Republican Party.
In her book, Handel makes it sound as though she was a scapegoat.
Nonetheless, Ossoff issued a statement early Wednesday saying, "This is already a remarkable victory. The eyes of the world are on us", he said at a canvass launch in Sandy Springs on Saturday afternoon".
"The discussion within Komen about addressing the objections of anti-abortion advocates intensified past year after Karen Handel was hired as senior vice president for public policy, several former Komen employees said".
"The decision, made in December, caused an uproar inside Komen".
She lost the race by just 2,500 votes and conceded to Rep. Nathan Deal (R-GA). "Bring it on!" he said. In addition to being anti-abortion rights, she's for lower income taxes, cutting regulations and stricter voter ID laws. It hasn't elected a Democrat to the House of Representatives since the Carter administration, and it was Newt Gingrich's district when he was Speaker of the House of Representatives in the 1990s.
But the one area where Handel did seem reticent was about the president. That left uncounted tens of thousands of votes, though Ossoff's support was lagging in Fulton County. "But my job is not to go to Congress as a rubber stamp for anybody".
"I think the president is interested in what happens here". There were plenty of others who were trying to out-Trump each other. And as I also point out, the top four GOP candidates in the primary got 58 percent of the vote.
"To me what's wonderful is that we continue to see this level shift across the country, a 20-point swing, that puts about 123 Republican seats potentially in play".
At the White House, spokesman Sean Spicer tried to do exactly that.
Veteran Democratic strategists say they're not anxious about sustaining the same level of enthusiasm.
Trump is certainly paying attention.