Geraint Thomas's attempt at winning the 2017 Giro d'Italia could be over after he went down hard in a crash which looks to have been caused by a police motorcycle.
There was little the Team Sunweb rider could do to avoid it, though, after clipping a poorly parked police motorbike, with Kelderman falling and taking the GC contenders with him.
Thomas, who was co-leading Sky's bid for the race's pink jersey alongside Spanish team-mate Landa, began the 149km ride from Montenero di Bisaccia only six seconds behind overnight leader Bob Jungels of Quick Step.
The pair were left behind as the leaders began the final climb up the Blockhaus and Thomas, who needed a couple of minutes to get back on his bike, appeared to be suffering from a shoulder injury.
Quintana went on to stamp his authority on the general classification, claiming the overall lead on the first big mountain stage.
Thomas lies 5 minutes 14 seconds behind new race leader and today's stage victor, Movistar's Nairo Quintana. Mollema is fourth, 51 seconds behind, and Nibali is fifth, 1:10 back.
And he was highly critical of race organisers when speaking to reporters following the end of a miserable day, as he said: "It's really disappointing, I don't know what to say". "We lost five minutes but I felt like I lost three or four of those on the side of the road".
"My shoulder, it popped out as well", added the Welsh rider.
Jungels fell the 12th place in the general classification, while Pinot and Dumoulin were able to stay within half a minute of Quintana.
"The bike had just stopped on the side of the road, we were all racing for position and someone in front of me hit it and we had nowhere to go, we all went straight down".
Sky boss Dave Brailsford rallied his troops and vowed they will "fight on".
"I'm sure the guy who was riding the motorbike sees that too and I'm not sure he'll be feeling too great".
Nibali was fifth, 59 seconds behind Quintana.
Thomas and Yates will have a rest day on Monday to consider their options, the British duo getting much-needed time to rest their tired and battered limbs ahead of stage 10 on Tuesday.